Streamlining drug discovery assays for cardiovascular disease using zebrafish

Zebrafish: from disease modeling to drug discovery.

The study of zebrafish, a leading model organism for developmental biology, is rapidly expanding to include human disease. Zebrafish models based on known disease mechanisms have been developed in several therapeutic areas, including blood diseases, diabetes, muscular dystrophy, neurodegenerative disease, angiogenesis and lipid metabolism. This review summarizes recent progress in disease model...

orphan nuclear receptors in drug discovery for parkinson’s disease

2012;5:s1

Novel Approaches and Assays in Drug Discovery

Systematizing serendipity for cardiovascular drug discovery.

Serendipity has played a significant role throughout the history of drug discovery in general and, in particular, throughout the history of cardiovascular medicine. The anticoagulant properties of dicoumarol were discovered after farmers observed that their cattle were dying of internal hemorrhaging after feeding on rotting sweet clover,1 and digitoxin was identified when the condition of a pat...

Cell-based Assays for Diagnostics, Drug and Target Discovery